Twins Kandi and Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life ...

At 670 pounds Ashley must live in her parents' home with her husband. Desperate to save her life and her marriage, she decides it's time for a drastic change. Can weight ...

Cynthia is a 610-lb single mother raising five kids. She's been focused on her children, but now realizes what her death would mean for them. As she battles her emotions ...

Weighing over 600 pounds, Kirsten is close to losing all her mobility. While she's trying to get control ofher obesity she's also in danger of losing her troubled son. Ca ...

After overcoming a dependence on drugs and alcohol, sneaking food is 660-lb Doug's last remaining vice. Can this husband, and father of 3 overcome his addictive personali ...

At 661 lbs, Erica regrets not keeping a promise to her mom. She hopes her siblings will help but they are reluctant based on her past failures. Each meal threatens Erica' ...

Diana, a once thin and active woman, is now a prisoner to her 620lb body. Desperate to break free of her food addiction, she trades the comfort of her apartment for a wei ...

Michael's massive 632lb body has left this husband and father dependent upon his family. If he doesn't learn to control his anger issues around food, lose weight, and add ...

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless. Trying to survive a family of addicts, she commits to Dr Nowzaradan's diet pro ...

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity. Now at 32, her future ...

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live, so his family takes a high-risk journey to Hou ...

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs. They're so massive with severe lymphedema, that gastric surgery is her only chance o ...

Steven Assanti weighs nearly 800-lbs and his brother/nemesis, Justin, is almost 600-lbs. Though the brothers can't stand each other, their father packs up the family to t ...

After a year on a weight loss program, Steven remains completely non-compliant, and Justin focuses on a new career instead of his diet... With neither brother close to be ...

Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300-lbs but still can't walk... And when Ashley is struck wit ...

Gastric surgery freed Brittani from her housebound life, but to achieve her ideal body she'll have to endure two more painful surgeries. Sean's super-obesity nearly kille ...

Surgery enables Teretha to finally return to family in Detroit but it soon threatens to undo all the progress she's made. After his weight loss surgery, trucker Chad gets ...

After losing 250lbs, Nikki is on her way to skin surgery that will transform her body. But when a close friend dies from weight loss surgery, Nikki's progress goes off tr ...

Devastated by the sudden loss of her son, Dottie's weight loss journey is in danger of going off track. June embarks on a plan to win approval for skin surgery. And Melis ...

Charity's daughter becomes dangerously obese; devastated by the death of her husband, Elroy, Milla must find a way to finally qualify for gastric bypass; checking in with ...

Joe was once 800lbs, housebound and alone. Now engaged, can he continue his weight loss? Pauline is on the verge of independence if only she can qualify for the skin surg ...

Surgery enabled Laura's independence but the complications nearly killed her and she's terrified about the next skin surgery. Chay revealed to her family she was transgen ...